Microbial and Neurovascular Predictors of Early Alzheimer's Subtypes
Official title: Microbial and Neurovascular Predictors for Subtypes of Prodromal Alzheimer's Disease
Funded at Medical College of Wisconsin · NIH-11446531 · Data updated 2026-11-12
Researchers will study how gut microbes and brain blood vessel health relate to early stages of Alzheimer's disease and its subtypes to help people understand their risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $645,037 |
| NIH project number | 1R01AG096741-01A1 |
| Project ID | NIH-11446531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults at risk for or in the prodromal stage of Alzheimer’s disease who consent to gut microbiome, biomarker, and neurovascular assessments.
✕Less likely to help
Individuals without prodromal Alzheimer's disease or those not participating in biomarker assessments may not receive direct benefit.
What this research studies
This project looks at how gut bacteria and vascular health in the brain may interact with early signs of Alzheimer’s disease. It uses human participants to examine biomarkers, cognitive changes, and imaging data to map how microbial factors relate to neurovascular function and disease progression. The goal is to identify patterns that could predict which prodromal patients will progress to dementia, with an emphasis on translating findings into earlier interventions. The study builds on preliminary data and aims to create a clearer picture of how the gut–brain–blood vessel axis influences Alzheimer’s pathways in humans.
Why it matters
Potential benefit: If successful, the research could lead to earlier risk detection and new avenues for interventions targeting the gut microbiome and brain blood vessels.
How similar studies have gone: Previous work suggests links between gut microbiota, neurovascular health, and AD biomarkers, but this study aims to clarify these relationships in prodromal stages.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Umfleet, Laura Glass — Medical College of Wisconsin
- Study coordinator: Umfleet, Laura Glass
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.