Mapping interactions between human cell surface proteins and secreted proteins
Official title: A Global Map of Interactions Among Human Cell Surface Proteins and Secreted Ligands
Funded at California Institute of Technology · NIH-11101052 · Data updated 2026-11-12
This study is looking at how proteins on the surface of human cells work together with proteins that are released by other cells, which is important for how our immune and nervous systems function, and it aims to help us understand these interactions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $178,914 |
| NIH project number | 3R01GM150125-03S1 |
| Project ID | NIH-11101052 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting the immune or nervous systems, as they may benefit from advancements in understanding cellular interactions.
✕Less likely to help
Patients with conditions unrelated to immune or nervous system functions may not receive direct benefits from this research.
What this research studies
This research aims to create a comprehensive map of how human cell surface proteins interact with secreted proteins, which are crucial for various cellular functions. By utilizing advanced techniques like multiplexed binding assays and single-cell sequencing, the researchers will explore the effects of these interactions on primary cells from the immune and nervous systems. This innovative approach involves testing millions of interactions to better understand cellular communication and function.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular interactions that may inform the development of targeted therapies for various diseases.
How similar studies have gone: Previous research has shown promise in mapping protein interactions, suggesting that this approach could yield significant insights into cellular mechanisms.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Zinn, Kai G — California Institute of Technology
- Study coordinator: Zinn, Kai G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.