Mapping how RNA binding proteins interact within cells
Official title: Mapping RNA Binding Protein Interactions Within Cellular Microenvironments
Funded at Case Western Reserve University · NIH-11125962 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells interact with RNA when the cells are under stress, helping us understand how these processes might go wrong in diseases, and it's designed for anyone interested in how our cells respond to tough situations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $402,500 |
| NIH project number | 5R35GM154771-02 |
| Project ID | NIH-11125962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to RNA metabolism disorders or those experiencing cellular stress responses.
✕Less likely to help
Patients with conditions unrelated to RNA binding protein interactions or cellular stress responses may not benefit from this research.
What this research studies
This research investigates the interactions between RNA binding proteins (RBPs) and RNA within cells, focusing on their precise locations and roles during cellular stress. By developing innovative tools, the study aims to create detailed maps of these interactions at a subcellular level, which is crucial for understanding how cells respond to stress and how these processes may go awry in diseases. The research will utilize cellular models that simulate halted protein synthesis to explore how RBPs regulate RNA localization, stability, and translation. Advanced computational methods will be employed to analyze the data and integrate it into existing knowledge of cellular RNA networks.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular responses to stress and the development of targeted therapies for diseases linked to dysregulated RNA metabolism.
How similar studies have gone: While the approach of mapping RBP interactions is innovative, similar studies have shown promise in understanding cellular processes, suggesting potential for success in this novel area.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Luna, Joseph M — Case Western Reserve University
- Study coordinator: Luna, Joseph M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.