Mapping heart development in embryos
5 D impulse mapping in the embryonic heart
This study is looking at how the heart develops in embryos and what goes wrong in cases of congenital heart defects, using special imaging tools to understand the signals that guide heart growth, which could help find better treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11031287 on NIH RePORTER |
What this research studies
This research investigates how the cardiac conduction system develops in embryos, particularly focusing on congenital heart defects (CHDs). By utilizing advanced imaging techniques like 2-photon microscopy, the study aims to connect molecular signaling with the physiological factors that influence heart development. The researchers will explore how these factors interact to better understand the mechanisms behind heart defects. This knowledge could lead to improved therapeutic strategies for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant parents, particularly those with a history of alcohol exposure during pregnancy or a family history of congenital heart defects.
Not a fit: Patients with fully developed hearts or those without congenital heart defects may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for congenital heart defects in newborns.
How similar studies have performed: Other research has shown success in using optical mapping techniques to study cardiac development, indicating that this approach has potential for meaningful insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Rollins, Andrew Martin — Case Western Reserve University
- Study coordinator: Rollins, Andrew Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.