Mapping brain lesions in multiple sclerosis using advanced sequencing techniques
Official title: High-spatial-resolution multi-omics sequencing of brain lesions in multiple sclerosis
Funded at University of Pennsylvania · NIH-10908636 · Data updated 2026-11-12
This study is looking at how different cells in brain lesions affect multiple sclerosis, especially the non-relapsing type, to find new ways to improve treatments and health for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $465,818 |
| NIH project number | 5DP2AI177913-02 |
| Project ID | NIH-10908636 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing non-relapsing progressive forms of the disease.
✕Less likely to help
Patients with other neurological disorders or those with early-stage relapsing forms of multiple sclerosis may not benefit from this research.
What this research studies
This research investigates the complex biology of brain lesions in multiple sclerosis (MS) by utilizing high-spatial-resolution multi-omics sequencing. It aims to understand how different cell types and their interactions contribute to the progression of MS, particularly in non-relapsing forms of the disease. By developing innovative molecular barcoding and microdevices, the project seeks to profile the spatial and phenotypic characteristics of cells within brain lesions, which could lead to new biomarkers and therapeutic strategies. Patients may benefit from insights that could improve treatment options and health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for multiple sclerosis by identifying new therapeutic targets.
How similar studies have gone: Previous research has shown promise in using multi-omics approaches to understand complex diseases, suggesting potential for success in this novel application.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Deng, Yanxiang — University of Pennsylvania
- Study coordinator: Deng, Yanxiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.