Liver Surgery Core for Human and Mouse Studies
Official title: Mouse and Human Liver Surgery Core
Funded at University of California Los Angeles · NIH-11594124 · Data updated 2026-11-12
A core group at UCLA helps collect human liver transplant samples and perform precise mouse liver surgery to study liver injury and transplant outcomes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2017 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $271,605 |
| NIH project number | 5P01AI120944-10 |
| Project ID | NIH-11594124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients undergoing liver transplantation or having donor liver tissue are eligible for sample donation and related data collection.
✕Less likely to help
The core activities do not directly benefit individual patients during the research visits beyond contributing to broader knowledge.
What this research studies
This grant supports Core B of a multi-project program to coordinate human sample collection from liver transplant patients, process the samples, and centralize data. It also provides specialized microsurgical liver procedures in mice to model ischemia-reperfusion injury and transplantation, with post-operative care and quality control. The Core ensures consistent sample handling, tracks patient data, and facilitates collaboration across projects to maximize use of both human and mouse liver tissues for translational studies. Overall, it aims to create high-quality biological resources and standardized surgical models that can accelerate understanding of liver transplant biology and potential therapies.
Why it matters
Potential benefit: If successful, patients could benefit from faster progress toward therapies that improve liver transplant outcomes and reduce complications.
How similar studies have gone: Prior work shows that centralized biobanking and standardized animal surgery models improve data quality and reproducibility in transplant research.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Kaldas, Fady M — University of California Los Angeles
- Study coordinator: Kaldas, Fady M
Related research
Other NIH-funded projects on the same topics.
-
Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Systems genetics of vascular smooth muscle phenotypes in heart disease
Aims to understand how genetic differences influence vascular smooth muscle cells to improve prevention and treatment of coronary artery disease.
-
Motivation for Alcohol Use in Humans and How It Can Be Measured
This grant explores how people are motivated to drink alcohol and tests a safe, controlled way to study that motivation to inform better treatments for alcohol use disorder.
-
Overcoming CAR T cell resistance with tumor-targeted IL-12 to boost anti-tumor immunity
Aims to make CAR T cell therapy work better for solid tumors by using tumor-focused IL-12 to boost the body’s attack on cancer.
-
PediCODE: A Biorepository and Consortium for CoDE - Congenital Diarrhea and Enteropathy
A nationwide effort to collect clinical data and patient-derived samples to uncover the genetic causes of congenital diarrhea and enteropathy and to build a resource that helps researchers study these diseases.
-
Mentor Moms+: a community-led plan to cut alcohol use and HIV risk during pregnancy in South Africa
A community-based program adapts a trusted peer-led model to help pregnant and lactating people reduce alcohol use and HIV risk in South Africa.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.