Lipid and DNA Insights into Heart and Metabolic Health in Samoan Adults
Official title: Lipidomics and structural genomics of cardiometabolic health in Samoan adults
Funded at University of Pittsburgh at Pittsburgh · NIH-11393301 · Data updated 2026-11-12
This research will study how fats in the blood and genetic differences relate to diabetes and heart health in Samoan adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 1, 2017 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $979,126 |
| NIH project number | 5R01HL133040-08 |
| Project ID | NIH-11393301 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults (21+) of Samoan heritage from Samoa or American Samoa who participate in the study and have consented to genetic and lipid analyses.
✕Less likely to help
Individuals not enrolled or not providing consent for genetic and lipid measurements may not directly benefit.
What this research studies
If you are a Samoan adult, this project will look at your blood fat profiles and your DNA to understand how genes and lipids contribute to cardiometabolic health. Researchers will generate detailed lipid measurements, examine how these lipids relate to genetic variation, and explore how lifestyle factors influence these connections in about 4,300 participants from Samoa and American Samoa. They will also analyze structural genetic differences in a subset of 1,285 individuals and see how those variations associate with lipid patterns and metabolic traits. The goal is to map how inherited DNA and blood fats shape diabetes and cardiovascular risk in this population.
Why it matters
Potential benefit: Could lead to better risk assessment and personalized prevention strategies for cardiometabolic diseases in Samoan communities.
How similar studies have gone: Previous work shows that lipid profiles and genetic variation can be linked to metabolic traits, supporting the potential promise of this approach.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Minster, Ryan Lee — University of Pittsburgh at Pittsburgh
- Study coordinator: Minster, Ryan Lee
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.