Linking Sleep, Activity, and Genes to Heart Health
Official title: An integrative study of gene-by-sleep and activity behavior interactions for cardiovascular health
Funded at Brigham and Women's Hospital · NIH-11426258 · Data updated 2026-11-12
This grant aims to understand how sleep and daily activity interact with our genes to affect heart health in a large, diverse group of people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,547,684 |
| NIH project number | 1R01HL187324-01 |
| Project ID | NIH-11426258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults whose health data were collected in large cohorts and who have information on sleep, activity, and genetics.
✕Less likely to help
Individuals without access to or whose data were not included in the contributing cohorts may not see direct benefits.
What this research studies
Researchers will analyze data from large cohorts to see how sleep duration and physical activity modify genetic risk for cardiovascular traits. They will use advanced methods to study both common and rare genetic variants and link findings to potential protein targets. The study will rely on existing data from projects like All of Us and CHARGE to explore these gene-environment interactions over time. The goal is to uncover biological pathways that could lead to better sleep and activity recommendations to prevent heart disease.
Why it matters
Potential benefit: If successful, findings could lead to personalized lifestyle guidelines that reduce heart disease risk based on a person’s genes and behavior.
How similar studies have gone: Previous studies have shown that sleep and activity can influence genetic risk for heart health, but methods for rare variants and longitudinal data are still developing.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Wang, Heming — Brigham and Women's Hospital
- Study coordinator: Wang, Heming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.