Kids’ Night-Time Blood Pressure and Kidney Disease in Glomerulopathy
Official title: Kids: Nocturnal Investigation into Glomerular Disease, Hypertension, and Transcriptomics (kNIGHT)
Funded at Feinstein Institute for Medical Research · NIH-11509059 · Data updated 2026-11-12
A study in children with proteinuric glomerulopathies will look at nighttime blood pressure, heart and kidney health, and related molecular markers to understand how these factors relate to future cardiovascular risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2026 |
| Award (this year) | $9,582 |
| NIH project number | 3R01HL162912-04S1 |
| Project ID | NIH-11509059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with proteinuric glomerulopathies (kidney disorders with protein in the urine).
✕Less likely to help
Children without proteinuric glomerulopathies or without nocturnal blood pressure abnormalities may be less likely to benefit.
What this research studies
This project follows children with proteinuric glomerulopathies to see how nocturnal blood pressure patterns relate to damage to the heart and other organs over time. Researchers will collect clinical data, monitor sleep and blood pressure at night, and analyze blood or tissue samples for molecular clues. The goal is to identify predictors that signal higher cardiovascular risk so doctors can better prevent long-term harm. The study builds on prior knowledge in adults and adapts it to a pediatric population to uncover age-specific risk factors.
Why it matters
Potential benefit: If successful, the findings could lead to earlier identification of at-risk children and guide personalized monitoring or interventions to protect heart and kidney health.
How similar studies have gone: Prior work in adults shows nocturnal blood pressure dysregulation links to worse outcomes; pediatric-specific data are emerging but more is needed.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Sethna, Christine B — Feinstein Institute for Medical Research
- Study coordinator: Sethna, Christine B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.