Investigating how specific proteins affect kidney cell development
Official title: Role of Etv4 and Etv5 in the self-renewal and differentiation of nephron progenitors
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11113820 · Data updated 2026-11-12
This study is looking at how two proteins, Etv4 and Etv5, help kidney cells grow and develop properly, and it could lead to new treatments for kidney diseases that affect many people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 9, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $445,399 |
| NIH project number | 5R01DK132052-03 |
| Project ID | NIH-11113820 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with congenital kidney abnormalities or those at risk for kidney diseases.
✕Less likely to help
Patients with fully developed and healthy kidney function are unlikely to benefit from this research.
What this research studies
This research focuses on the roles of two proteins, Etv4 and Etv5, in the development of kidney cells, particularly nephron progenitor cells. Using a mouse model, the researchers will explore how the absence of these proteins leads to kidney abnormalities and affects the balance between cell self-renewal and differentiation. By analyzing genetic data, they aim to understand the signaling pathways involved in kidney development, which could provide insights into kidney diseases. Patients may benefit from this research as it could lead to new therapeutic strategies for kidney-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for kidney diseases by enhancing our understanding of kidney cell development.
How similar studies have gone: Other research has shown success in understanding kidney development through similar genetic approaches, indicating that this area of study is promising.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Cebrian Ligero, Cristina — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Cebrian Ligero, Cristina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.