Investigating how specific proteins affect kidney cell development
Role of Etv4 and Etv5 in the self-renewal and differentiation of nephron progenitors
This study is looking at how two proteins, Etv4 and Etv5, help kidney cells grow and develop properly, and it could lead to new treatments for kidney diseases that affect many people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11113820 on NIH RePORTER |
What this research studies
This research focuses on the roles of two proteins, Etv4 and Etv5, in the development of kidney cells, particularly nephron progenitor cells. Using a mouse model, the researchers will explore how the absence of these proteins leads to kidney abnormalities and affects the balance between cell self-renewal and differentiation. By analyzing genetic data, they aim to understand the signaling pathways involved in kidney development, which could provide insights into kidney diseases. Patients may benefit from this research as it could lead to new therapeutic strategies for kidney-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with congenital kidney abnormalities or those at risk for kidney diseases.
Not a fit: Patients with fully developed and healthy kidney function are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for kidney diseases by enhancing our understanding of kidney cell development.
How similar studies have performed: Other research has shown success in understanding kidney development through similar genetic approaches, indicating that this area of study is promising.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Cebrian Ligero, Cristina — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Cebrian Ligero, Cristina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.