Investigating how oxidative stress affects brain development
Official title: Redox signaling during neurodevelopment and sensitivity to oxidative stress
Funded at University of California, San Diego · NIH-11057086 · Data updated 2026-11-12
This study is looking at how stress in the brain affects its development, especially in relation to genetics and the environment, to help us understand and improve treatments for conditions like autism, using special tools to see how brain cells react during important growth stages in mice.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 20, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $159,200 |
| NIH project number | 1R03ES036405-01A1 |
| Project ID | NIH-11057086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic predispositions to developmental disorders, particularly autism spectrum disorder.
✕Less likely to help
Patients who do not have developmental disorders or genetic susceptibilities related to oxidative stress may not benefit from this research.
What this research studies
This research explores the role of oxidative stress in the development of the brain, particularly focusing on how genetic and environmental factors contribute to developmental disorders. Using a specialized fluorescent biosensor, the study will observe the redox state of neurons during critical stages of development in mice. The research will also examine how exposure to harmful substances like paraquat and acetaminophen affects these neurons, potentially leading to better understanding and treatment of conditions like autism spectrum disorder.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for preventing or treating developmental disorders linked to oxidative stress.
How similar studies have gone: Previous research has shown that understanding oxidative stress pathways can lead to significant advancements in treating developmental disorders, suggesting this approach has potential for success.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Campbell, Melissa Mckenzie — University of California, San Diego
- Study coordinator: Campbell, Melissa Mckenzie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.