Investigating how nutrient signaling affects mitochondrial function and aging
Nutrient signaling at ER-Mitochondrial contacts and age-related mitochondrial dysfunction
This study is looking at how what we eat affects the tiny powerhouses in our cells, called mitochondria, especially when we fast and as we get older, to find ways to keep them healthy for people as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11101319 on NIH RePORTER |
What this research studies
This research explores the relationship between nutrient signaling and mitochondrial function, particularly at the contact points between the endoplasmic reticulum and mitochondria. It aims to understand how fasting influences mitochondrial dynamics and whether these processes change with age. By examining the role of specific proteins and signaling pathways, the study seeks to uncover mechanisms that could lead to improved mitochondrial health in aging individuals. The research will involve both laboratory experiments and analysis of mammalian systems to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related decline in mitochondrial function or related health issues.
Not a fit: Patients with acute mitochondrial diseases unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving mitochondrial function and reducing age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dynamics and nutrient signaling, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Singh, Rajat — University of California Los Angeles
- Study coordinator: Singh, Rajat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.