Investigating how lipid metabolism affects lung disease
Official title: Role of GM-CSF and impaired lipid metabolism in the pathogenesis of PAP
Funded at University of California Los Angeles · NIH-10985295 · Data updated 2026-11-12
This study is looking into how problems with fat processing in the body might lead to pulmonary alveolar proteinosis (PAP), a serious lung condition, and aims to find new ways to help people with PAP feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 18, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $170,532 |
| NIH project number | 1K08HL166970-01A1 |
| Project ID | NIH-10985295 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary alveolar proteinosis or those experiencing related pulmonary issues.
✕Less likely to help
Patients with other unrelated pulmonary conditions or those not diagnosed with PAP may not benefit from this research.
What this research studies
This research focuses on understanding the role of lipid metabolism in the development of pulmonary alveolar proteinosis (PAP), a serious lung condition. The principal investigator, Dr. Elinor Lee, will conduct mechanistic studies to explore how dysregulation of lipids contributes to this disease. By collaborating with experts in lipid biology and immunology, the research aims to uncover new insights that could lead to better treatments for patients with PAP. The project will also involve training in advanced techniques such as gene editing and biostatistics to enhance the research outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients suffering from pulmonary alveolar proteinosis.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism's role in various pulmonary diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Lee, Elinor — University of California Los Angeles
- Study coordinator: Lee, Elinor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.