Investigating how high fibrinogen levels affect brain function and memory after traumatic brain injury.
Official title: Hyperfibrinogenemia and sphingolipid-mediated cerebrovascular permeability and memory impairment during TBI
Funded at University of South Florida · NIH-10855710 · Data updated 2026-11-12
This study is looking at how high levels of a protein called fibrinogen in the blood might affect memory and thinking skills in people with Alzheimer's and similar conditions, especially after a brain injury, to find ways to help improve brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $749,987 |
| NIH project number | 1R56NS129979-01 |
| Project ID | NIH-10855710 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Alzheimer's disease or related cognitive impairments, particularly those who have experienced a traumatic brain injury.
✕Less likely to help
Patients without a history of traumatic brain injury or those not affected by Alzheimer's disease or related cognitive disorders may not benefit from this research.
What this research studies
This research explores the connection between elevated fibrinogen levels in the blood and cognitive decline, particularly in Alzheimer's disease and related disorders. It focuses on how these high levels can lead to increased permeability of blood vessels in the brain following traumatic brain injury, which may contribute to memory impairment. The study uses advanced techniques to analyze the mechanisms involved, including the role of specific proteins and pathways that are activated during this process. By understanding these interactions, the research aims to identify potential therapeutic targets to improve brain health after injury.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help protect memory and cognitive function in patients with Alzheimer's disease and those who have experienced traumatic brain injuries.
How similar studies have gone: Previous research has shown promising results in understanding the role of fibrinogen in cognitive decline, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Lominadze, David — University of South Florida
- Study coordinator: Lominadze, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.