Investigating how smell loss relates to memory problems in Alzheimer's disease
Linking olfactory deficits to memory impairment and AD neurodegeneration
This study is looking at how problems with smell might be linked to memory issues in people with Alzheimer's disease, and it’s for anyone interested in understanding how these changes happen as we age, with the hope of finding better ways to spot Alzheimer's early.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11079665 on NIH RePORTER |
What this research studies
This research explores the connection between olfactory deficits and memory impairment in individuals with Alzheimer's disease (AD). By using advanced imaging techniques like functional MRI, the study aims to identify how neurodegeneration affects the brain's olfactory network and its relationship with memory functions. The researchers will examine both cognitively normal individuals and those with mild cognitive impairment to understand age-related changes and the progression of cognitive decline. The ultimate goal is to develop better diagnostic markers for early detection of AD.
Who could benefit from this research
Good fit: Ideal candidates include older adults, particularly those experiencing mild cognitive impairment or early signs of memory loss.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early diagnosis and intervention strategies for Alzheimer's disease.
How similar studies have performed: Previous research has indicated that olfactory deficits can be linked to cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Karunanayaka, Prasanna Rasika — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Karunanayaka, Prasanna Rasika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.