Investigating how changes in mitochondrial function are linked to aging and inflammation
Official title: Pathological cardiolipin remodeling links mitochondrial dysfunction to inflammaging
Funded at University of Texas Hlth Science Center · NIH-11057853 · Data updated 2026-11-12
This study is looking at how problems with tiny parts of our cells, called mitochondria, and ongoing inflammation as we get older might be connected, especially focusing on a special fat called cardiolipin and an enzyme called ALCAT1, to find ways to help older adults stay healthier.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | November 15, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $78,750 |
| NIH project number | 1R03AG086958-01A1 |
| Project ID | NIH-11057853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues, particularly those with conditions linked to mitochondrial dysfunction and inflammation.
✕Less likely to help
Patients who are younger and do not have any age-related diseases or mitochondrial dysfunction may not benefit from this research.
What this research studies
This research explores the relationship between mitochondrial dysfunction and chronic inflammation as we age. It focuses on a specific phospholipid called cardiolipin, which is crucial for mitochondrial health. The study aims to understand how the remodeling of cardiolipin contributes to age-related diseases by examining the role of an enzyme called ALCAT1. By investigating these mechanisms, the research seeks to uncover potential therapeutic targets for improving health in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases.
How similar studies have gone: Previous studies have shown promising results in understanding the role of mitochondrial dysfunction in aging, suggesting that this research builds on established findings.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Zhang, Jun — University of Texas Hlth Science Center
- Study coordinator: Zhang, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.