Investigating how certain growth factors affect thymus size and function as we age
Official title: The role of medullary thymic epithelial cell-derived growth factors in regulating thymus growth and atrophy
Funded at University of Texas Hlth Science Center · NIH-10821423 · Data updated 2026-11-12
This study is looking at how certain growth factors from thymic cells affect the thymus gland's size and function, especially as we get older, to find ways to help boost the immune system in older adults who may struggle with infections and vaccines.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | April 15, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $193,750 |
| NIH project number | 5R21AG081709-02 |
| Project ID | NIH-10821423 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related decline in immune function.
✕Less likely to help
Patients who are not elderly or do not have issues related to immune function decline may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific growth factors produced by thymic epithelial cells in regulating the growth and atrophy of the thymus gland, which is crucial for producing T lymphocytes, essential components of the immune system. As people age, the thymus shrinks, leading to a decline in new T cell production, which can affect the body's ability to respond to infections and vaccines. By using advanced informatic techniques, the researchers aim to identify the molecular mechanisms behind thymic atrophy and explore potential ways to reverse this process, thereby improving immune function in older adults.
Why it matters
Potential benefit: If successful, this research could enhance immune responses in older adults, potentially improving their ability to fight infections and respond to vaccinations.
How similar studies have gone: Previous research has shown promising results in understanding thymic function and regeneration, suggesting that this approach could lead to significant advancements in treating age-related immune decline.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Griffith, Ann Venables — University of Texas Hlth Science Center
- Study coordinator: Griffith, Ann Venables
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.