Investigating how antibiotics affect gut bacteria and depression
A Model of Antibiotic-induced Gut Dysbiosis and Depressive Symptomatology
This study is looking at how antibiotics might change the bacteria in our gut and how that could affect feelings of depression, using marmosets to help us understand this connection better and explore possible treatments like fecal transplants.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Omaha NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11055356 on NIH RePORTER |
What this research studies
This research explores the connection between gut bacteria and depression, particularly how antibiotics may lead to changes in gut microbiome and contribute to depressive symptoms. Using a nonhuman primate model, the common marmoset, the study will examine how antibiotic treatment alters gut bacteria and impacts behavior. The research aims to understand the mechanisms behind these changes and evaluate potential treatments, such as fecal microbiota transplantation, to alleviate depression caused by antibiotic use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced depression following antibiotic treatment.
Not a fit: Patients who have not been treated with antibiotics or do not suffer from depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for depression linked to antibiotic use.
How similar studies have performed: While the specific approach using nonhuman primates is novel, there is emerging evidence suggesting that gut microbiome alterations can influence mental health outcomes.
Where this research is happening
Omaha, United States
- University of Nebraska Omaha — Omaha, United States (Active)
Researchers
- Principal investigator: Clayton, Jonathan Brent — University of Nebraska Omaha
- Study coordinator: Clayton, Jonathan Brent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.