Investigating how a specific receptor affects sleep changes caused by estrogen.
Official title: A Role for the Orphan Receptor, GPR37, in Estradiol-induced Changes in Sleep-Wake States
Funded at University of Maryland Baltimore · NIH-11006242 · Data updated 2026-11-12
This study is looking at how the GPR37 receptor helps estrogen affect sleep patterns in women, especially during times like pregnancy and menopause, to find new ways to help with sleep problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 30, 2023 |
| Project end | August 29, 2026 |
| Funding year | 2024 |
| Award (this year) | $49,986 |
| NIH project number | 5F30HL168851-02 |
| Project ID | NIH-11006242 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing sleep disturbances linked to hormonal fluctuations, such as during pregnancy or menopause.
✕Less likely to help
Patients who do not experience sleep issues or those whose sleep disturbances are unrelated to hormonal changes may not benefit from this research.
What this research studies
This research explores the role of the GPR37 receptor in how estrogen influences sleep-wake cycles, particularly in women. It focuses on understanding the mechanisms by which hormonal fluctuations, such as those occurring during pregnancy and menopause, affect sleep patterns. By studying the brain's sleep centers and the interaction of estrogen with specific receptors, the research aims to identify potential targeted treatments for sleep disorders in women. The approach includes experiments on animal models to observe the effects of estrogen and adenosine on sleep regulation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for women suffering from sleep disorders related to hormonal changes.
How similar studies have gone: Previous research has indicated that hormonal influences on sleep are significant, suggesting that this approach may yield valuable insights, although the specific role of GPR37 is less explored.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Kruk, Katie — University of Maryland Baltimore
- Study coordinator: Kruk, Katie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.