Investigating brain cell dysfunction in Down Syndrome using advanced cell models
Understanding neuronal dysfunction in Down Syndrome using assembloids and xenotransplanted cortical organoids
This study is looking at how Down Syndrome affects brain cells and can lead to memory problems and a higher chance of developing Alzheimer's, using special lab-grown brain cells to better understand these challenges in a friendly and relatable way.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10944356 on NIH RePORTER |
What this research studies
This research focuses on understanding how Down Syndrome, caused by an extra copy of chromosome 21, leads to cognitive challenges and increases the risk of Alzheimer's disease. The team will create specialized brain cell models from induced pluripotent stem cells to study how these cells behave and connect in individuals with Down Syndrome. By using advanced techniques like calcium imaging, they aim to uncover the underlying mechanisms of neuronal dysfunction that contribute to cognitive deficits. This approach allows for a more accurate representation of human brain activity compared to traditional animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down Syndrome, particularly those experiencing cognitive challenges.
Not a fit: Patients without Down Syndrome or those who do not exhibit cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for cognitive impairments associated with Down Syndrome and Alzheimer's disease.
How similar studies have performed: While this approach is innovative, similar studies using advanced cellular models have shown promise in understanding other neurological conditions.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Zeldich, Ella — Boston University Medical Campus
- Study coordinator: Zeldich, Ella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.