Intensive Blood Pressure Control During Breast Cancer Treatment
Official title: Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial
Funded at Sloan-Kettering Inst Can Research · NIH-11333327 · Data updated 2026-11-12
A study to see whether tighter blood pressure control helps patients with breast cancer who are receiving treatments that can affect the heart.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $580,036 |
| NIH project number | 5R37CA273923-04 |
| Project ID | NIH-11333327 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with breast cancer receiving treatments known to carry cardiotoxic risks who also have hypertension or elevated cardiovascular risk.
✕Less likely to help
Patients without hypertension or those for whom aggressive BP control is not clinically appropriate may see minimal direct benefit.
What this research studies
This project looks at managing high blood pressure more aggressively in people undergoing breast cancer therapy that can harm the heart. It will monitor cardiovascular health and consider how better BP control might reduce heart-related side effects during and after treatment. Researchers will likely use existing patient data, measurements, and treatment details to compare outcomes between standard and intensive blood pressure strategies. The goal is to identify a BP approach that protects heart function without compromising cancer care. If successful, this could change how doctors support heart health for many breast cancer patients.
Why it matters
Potential benefit: If the approach works, patients may experience fewer heart problems and better overall health during and after cancer treatment.
How similar studies have gone: Prior research suggests BP control reduces cardiovascular risk, but this cancer-specific approach is novel and targets treatment-related cardiotoxicity.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Yu, Anthony Francis — Sloan-Kettering Inst Can Research
- Study coordinator: Yu, Anthony Francis
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.