Controlling blood pressure to reduce heart risks during breast cancer treatment
Official title: Intensive Blood Pressure Control During Cardiotoxic Breast Cancer Treatment (PROTECT) Trial
Funded at Sloan-Kettering Inst Can Research · NIH-11094035 · Data updated 2026-11-12
This study is looking at how closely managing blood pressure can help protect the hearts of breast cancer patients who are receiving certain treatments, making sure they stay healthy while fighting cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $580,036 |
| NIH project number | 5R37CA273923-03 |
| Project ID | NIH-11094035 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are breast cancer patients who have hypertension and are receiving cardiotoxic cancer therapies.
✕Less likely to help
Patients who do not have hypertension or are not undergoing cardiotoxic cancer treatments may not benefit from this research.
What this research studies
This research investigates how intensive blood pressure control can help reduce cardiovascular risks in breast cancer patients undergoing treatment. It focuses on patients who may experience heart-related side effects from cancer therapies, particularly those using anthracyclines and HER2-targeted agents. By monitoring and managing blood pressure more aggressively, the study aims to prevent heart damage and improve overall treatment outcomes. The approach includes careful tracking of blood pressure and adjusting medications as needed to ensure optimal heart health during cancer treatment.
Why it matters
Potential benefit: If successful, this research could significantly lower the risk of heart complications for breast cancer patients undergoing treatment.
How similar studies have gone: Previous trials have shown that intensive blood pressure control can reduce cardiovascular risks, but this specific approach in cancer patients is novel and has not been extensively tested.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Yu, Anthony Francis — Sloan-Kettering Inst Can Research
- Study coordinator: Yu, Anthony Francis
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.