Integrative Analysis Core for Longevity and Dementia Research
Official title: Integrative Analysis Core
Funded at Translational Genomics Research Inst · NIH-11399392 · Data updated 2026-11-12
A broad, shared analysis resource aims to bring together multiple studies on aging, longevity, and Alzheimer’s disease to better understand how genetics and other factors influence healthy aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Translational Genomics Research Inst NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 30, 2004 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,021,354 |
| NIH project number | 5U19AG023122-18 |
| Project ID | NIH-11399392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Alzheimer’s disease or related dementias, and diverse aging populations, may contribute data or samples through related studies in the consortium.
✕Less likely to help
Participants not directly involved in genetic or biomarker analyses may not experience immediate benefits.
What this research studies
This grant funds a centralized hub that combines data and methods from five projects to reveal how longevity and brain aging relate across diverse populations. It will build tools and infrastructure to integrate results, compare findings, and place individual discoveries into a larger context. The goal is to help researchers identify mechanisms that influence lifespan and healthspan, which could ultimately inform strategies to support aging well and prevent dementia.
Why it matters
Potential benefit: Could accelerate discoveries that improve healthy aging and reduce dementia risk by linking findings across studies.
How similar studies have gone: Past integrative analyses have helped validate findings across cohorts, supporting the value of data triangulation.
Where this research is happening
-
Translational Genomics Research Inst
Phoenix, United States Active
Researchers
- Principal investigator: Schork, Nicholas Joseph — Translational Genomics Research Inst
- Study coordinator: Schork, Nicholas Joseph
Related research
Other NIH-funded projects on the same topics.
-
CLU's role in Alzheimer's disease pathogenesis
Researchers are studying how the CLU gene may drive brain changes in Alzheimer's disease and how targeting CLU could lead to safer treatments.
-
How glioblastoma changes across the tumor and over time during treatment
This work maps how glioblastoma tumors shift their cell types and interactions during and after treatment to find weaknesses that could help people with recurrent GBM.
-
Understanding how early changes in lungs lead to progressive fibrotic disease
This grant studies the cells and genes involved in starting and advancing pulmonary fibrosis to uncover why some people progress to severe disease.
-
Understanding Why Some People Age Well Despite Alzheimer’s and Related Dementias
Researchers are building patient-derived cell models to study why some people resist or slow down dementia and how aging affects brain cells, with a focus on Alzheimer’s Disease and related disorders.
-
Drugs that slow aging and extend healthy years
A research project aims to find and test medicines that could slow aging and help people stay healthier longer.
-
Extreme longevity and brain health in centenarians and families
This grant studies why some people live to 100 with strong thinking skills and how genes and biomarkers relate to Alzheimer’s disease and related dementias, aiming to help others stay cognitively healthy as they age.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.