NIH-funded research NIH-funded research

Drugs that slow aging and extend healthy years

Official title: Drug Targeting, Testing, and Development

Funded at Translational Genomics Research Inst · NIH-11399388 · Data updated 2026-11-12

A research project aims to find and test medicines that could slow aging and help people stay healthier longer.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionTranslational Genomics Research Inst
NIH-funded
Lab location1 site (Phoenix, United States)
Project startSeptember 30, 2004
Project endAugust 31, 2029
Funding year2026
Award (this year)$1,366,719
NIH project number5U19AG023122-18
Project IDNIH-11399388 on NIH RePORTER

Who could benefit from this research

Could help

Adults, including those around middle age, who might participate in future human studies or be involved through related samples or early trials.

Less likely to help

The project may not directly benefit any individual patient in the short term but could influence future therapies.

What this research studies

This project combines computer-based and laboratory methods to identify promising drugs that may slow aging. One team searches public data and chemical information to pick candidates, while another tests these candidates in mice and explores early human and dog studies. The goal is to find “geroprotectors” that influence aging-related changes and improve healthspan. Researchers will use aging-rate indicators measured in tissues and fluids to evaluate potential effects. If successful, this work could guide future human trials of aging-stopping therapies.

Why it matters

Potential benefit: If successful, the research could lead to new drugs that delay aging-related health decline and extend healthy years.

How similar studies have gone: Prior work with aging-rate indicators and geroprotectors has shown promise in animals, with exploratory human data supporting potential effects.

Where this research is happening

  • Translational Genomics Research Inst
    Phoenix, United States
    Active

Researchers

  • Principal investigator: Miller, Richard a — Translational Genomics Research Inst
  • Study coordinator: Miller, Richard a

Related research

Other NIH-funded projects on the same topics.

  • CLU's role in Alzheimer's disease pathogenesis

    Researchers are studying how the CLU gene may drive brain changes in Alzheimer's disease and how targeting CLU could lead to safer treatments.

    NIH research Translational Genomics Research Inst · Phoenix, United States · NIH-11622617

  • How glioblastoma changes across the tumor and over time during treatment

    This work maps how glioblastoma tumors shift their cell types and interactions during and after treatment to find weaknesses that could help people with recurrent GBM.

    NIH research Translational Genomics Research Inst · Phoenix, United States · NIH-11457140

  • Understanding how early changes in lungs lead to progressive fibrotic disease

    This grant studies the cells and genes involved in starting and advancing pulmonary fibrosis to uncover why some people progress to severe disease.

    NIH research Translational Genomics Research Inst · Phoenix, United States · NIH-11406083

  • Integrative Analysis Core for Longevity and Dementia Research

    A broad, shared analysis resource aims to bring together multiple studies on aging, longevity, and Alzheimer’s disease to better understand how genetics and other factors influence healthy aging.

    NIH research Translational Genomics Research Inst · Phoenix, United States · NIH-11399392

  • Understanding Why Some People Age Well Despite Alzheimer’s and Related Dementias

    Researchers are building patient-derived cell models to study why some people resist or slow down dementia and how aging affects brain cells, with a focus on Alzheimer’s Disease and related disorders.

    NIH research Translational Genomics Research Inst · Phoenix, United States · NIH-11399390

  • Extreme longevity and brain health in centenarians and families

    This grant studies why some people live to 100 with strong thinking skills and how genes and biomarkers relate to Alzheimer’s disease and related dementias, aiming to help others stay cognitively healthy as they age.

    NIH research Translational Genomics Research Inst · Phoenix, United States · NIH-11399386

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.