Extreme longevity and brain health in centenarians and families
Official title: Extreme Longevity, Cognitive Impairment, Alzheimer's Disease and Related Dementias
Funded at Translational Genomics Research Inst · NIH-11399386 · Data updated 2026-11-12
This grant studies why some people live to 100 with strong thinking skills and how genes and biomarkers relate to Alzheimer’s disease and related dementias, aiming to help others stay cognitively healthy as they age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Translational Genomics Research Inst NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 30, 2004 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,552,501 |
| NIH project number | 5U19AG023122-18 |
| Project ID | NIH-11399386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Centenarians, their offspring, and individuals with a family history of longevity or ADRD may be eligible for related studies or data contributions.
✕Less likely to help
People without a family history of longevity or ADRD or those not contributing samples or data may not directly benefit.
What this research studies
Researchers will combine genetic data with proteomic and metabolomic profiles from centenarians, their offspring, and related groups to identify signatures linked to extreme aging and preserved cognition. The project builds on an existing Longevity Consortium effort to expand multi-omics analyses and discover genetic factors that protect against cognitive impairment and ADRD. By integrating new data and analyses, they hope to pinpoint targets that could guide healthy aging therapies and prevention strategies. The work is designed to translate complex molecular patterns into a clearer understanding of why certain individuals maintain brain health despite age.
Why it matters
Potential benefit: If successful, the research could reveal biomarkers and genetic targets that inform interventions to promote healthy brain aging and reduce ADRD risk.
How similar studies have gone: Previous analyses have identified proteomic and metabolomic signatures linked to longevity and cognitive outcomes, supporting the approach’s potential.
Where this research is happening
-
Translational Genomics Research Inst
Phoenix, United States Active
Researchers
- Principal investigator: Sebastiani, Paola — Translational Genomics Research Inst
- Study coordinator: Sebastiani, Paola
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.