Proteomics-guided matching of lung cancer tumors to preclinical models
Official title: Proteomics-driven precision molecular mapping of patient tumors to preclinical models in lung cancer
Funded at Univ of North Carolina Chapel Hill · NIH-11508348 · Data updated 2026-11-12
This grant aims to improve how we match a patient’s lung cancer tumor to the right preclinical models using protein data.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | March 11, 2025 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $137,034 |
| NIH project number | 7R21CA288901-02 |
| Project ID | NIH-11508348 on NIH RePORTER |
Who could benefit from this research
✓Could help
Lung cancer patients whose tumors are available for molecular profiling and model mapping.
✕Less likely to help
Patients whose tumor samples cannot be profiled or mapped to preclinical models may not directly benefit.
What this research studies
Researchers will use proteomic profiling to better map patient tumor samples to lung cancer models, aiming to improve the relevance of preclinical testing. They plan to apply a high-throughput proteomics platform called RPPA to identify protein markers that reflect tumor biology and potential treatment targets. The work focuses on linking real patient tumors with the most predictive models so future therapies can be tested more quickly and accurately. The project builds on prior RPPA work and plans to expand profiling of lung cancer models to increase the chances of finding effective, personalized strategies.
Why it matters
Potential benefit: If successful, patients could benefit from more accurate preclinical models that speed the development of targeted therapies for lung cancer.
How similar studies have gone: Prior RPPA-based approaches have shown promise in identifying functional protein markers and improving model relevance, but broader clinical translation is ongoing.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Li, Jun — Univ of North Carolina Chapel Hill
- Study coordinator: Li, Jun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.