Improving wound healing by targeting neutrophil responses.
Official title: Targeting neutrophil clearance to harness myeloid responses for wound healing.
Funded at Upstate Medical University · NIH-11096841 · Data updated 2026-11-12
This study is looking at how a type of white blood cell called neutrophils can be used to help heal stubborn wounds in people with obesity and diabetes, and it aims to create a special nano-drug that boosts these cells to improve healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $158,763 |
| NIH project number | 3R01GM144624-02S1 |
| Project ID | NIH-11096841 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who suffer from chronic wounds, particularly those with obesity or diabetes.
✕Less likely to help
Patients with acute wounds or those without metabolic conditions like obesity or diabetes may not benefit from this research.
What this research studies
This research investigates how neutrophils, a type of white blood cell, can be targeted to improve wound healing, particularly in patients with chronic wounds influenced by obesity and diabetes. The study will explore the mechanisms by which neutrophils are cleared from the bone marrow and how this process affects the body's ability to heal wounds. By using both mouse models and human samples, the researchers aim to develop a nano-drug that can enhance neutrophil function and promote better healing outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve wound healing for patients with chronic wounds.
How similar studies have gone: Previous research has shown promising results in targeting immune responses for wound healing, suggesting that this approach may be effective.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Urao, Norifumi — Upstate Medical University
- Study coordinator: Urao, Norifumi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.