Improving treatment options for inflammatory bowel disease using small molecules
Official title: Optimization of small molecule immunomodulators as combination therapy for IBD
Funded at Weill Medical Coll of Cornell Univ · NIH-11072010 · Data updated 2026-11-12
This study is looking for new ways to improve treatment for inflammatory bowel disease (IBD) by creating small molecules that work better with your immune system, aiming to find combinations that help manage the condition with fewer side effects than current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 10, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $664,128 |
| NIH project number | 5R01DK137299-02 |
| Project ID | NIH-11072010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease who have not responded adequately to existing treatments.
✕Less likely to help
Patients with mild or well-controlled inflammatory bowel disease may not benefit from this research.
What this research studies
This research focuses on developing new small molecule immunomodulators to enhance treatment for inflammatory bowel disease (IBD). It aims to identify effective combinations of therapies that target specific immune cell receptors, which could lead to better management of the disease. By utilizing a novel platform called Small Molecules from Antibody Pharmacophores (SMAPs), the researchers will create small molecules that minimize the risk of adverse effects compared to current protein-based therapies. This approach seeks to address the high rates of treatment failure seen with existing therapies.
Why it matters
Potential benefit: If successful, this research could provide more effective and safer treatment options for patients with inflammatory bowel disease.
How similar studies have gone: While the approach of using small molecules for immunomodulation is innovative, similar strategies targeting immune pathways have shown promise in other inflammatory conditions.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Gabr, Moustafa — Weill Medical Coll of Cornell Univ
- Study coordinator: Gabr, Moustafa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.