Improving rat genome assembly to better understand complex diseases
Long-read assembly and annotation of rat genomes that are important models of complex genetic disease
This study is working to make the genetic information about rats even better, which will help scientists understand diseases like brain disorders and addiction, ultimately leading to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11080198 on NIH RePORTER |
What this research studies
This research focuses on enhancing the genomic resources for rats, which are important models for studying various medical conditions, including brain disorders and addiction. By improving the quality of the rat genome assembly and gene annotation, the project aims to facilitate more accurate genetic investigations into disease susceptibility and mechanisms. This work will utilize advanced genomic techniques to create a more comprehensive reference for different rat strains, ultimately aiding in the understanding of complex genetic diseases. Patients may benefit indirectly through advancements in treatments derived from improved animal model research.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals affected by neurological disorders, addiction, or other conditions that are modeled in rats.
Not a fit: Patients with conditions not modeled in rats or those unrelated to the genetic investigations of this research may not receive direct benefits.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for complex diseases that affect humans.
How similar studies have performed: Previous research has shown that improving genomic resources for animal models can significantly enhance the understanding of human diseases, indicating a promising approach.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Doris, Peter a — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Doris, Peter a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.