National primate embryo resource for human genetic disease models
Official title: A National NHP Embryo Resource of Human Genetic Disease Models
Funded at Oregon Health & Science University · NIH-11253307 · Data updated 2026-11-12
They are building a national collection of primate embryos that carry human-like genetic mutations to help speed development of new treatments for inherited diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $638,810 |
| NIH project number | 5R24OD034055-04 |
| Project ID | NIH-11253307 on NIH RePORTER |
Who could benefit from this research
✓Could help
This project does not enroll patients; it is designed to support research relevant to people with rare inherited genetic conditions.
✕Less likely to help
People with common non-genetic conditions or those looking for direct clinical care will not receive benefit from this resource.
What this research studies
This project will collect, preserve, and share embryos and reproductive materials from non-human primates that carry genetic changes similar to human inherited diseases. Teams will use assisted reproduction and cryopreservation to increase availability of rare disease-model animals and enable sharing across National Primate Research Centers. The resource is intended to support preclinical testing of gene and precision therapies that require large-animal models before human trials. Patients are not enrolled, but the work aims to make it easier and faster to develop treatments for people with rare genetic conditions.
Why it matters
Potential benefit: If successful, the resource could speed and improve preclinical testing of therapies for rare human genetic diseases, potentially accelerating safe human trials.
How similar studies have gone: Individual non-human primate disease models have supported preclinical work, but creating a coordinated national embryo bank is a novel approach that has not been widely used before.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Sherman, Larry S. — Oregon Health & Science University
- Study coordinator: Sherman, Larry S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.