Investigating how RNA structure changes contribute to genetic diseases
Official title: Variant induced RNA structure change in human genetic disease
Funded at Univ of North Carolina Chapel Hill · NIH-11088257 · Data updated 2026-11-12
This study is looking at how the shape of RNA affects how genes work after they are copied, which could help us understand more about certain diseases and genetic disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 1, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $416,440 |
| NIH project number | 5R35GM140844-05 |
| Project ID | NIH-11088257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with known genetic variants associated with human diseases.
✕Less likely to help
Patients without genetic variants or those with conditions unrelated to RNA structure changes may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA structure in regulating gene expression after transcription. By examining how specific genetic variants affect RNA structure, the study aims to uncover the mechanisms behind various human diseases. The approach combines computational predictions with experimental techniques to analyze RNA in living cells, assessing how these structural changes impact processes like translation and mRNA stability. Ultimately, this research seeks to provide insights into disease mechanisms and improve our understanding of genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of genetic diseases and potential therapeutic targets.
How similar studies have gone: Other research has shown promise in understanding RNA structure's role in gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Laederach, Alain T — Univ of North Carolina Chapel Hill
- Study coordinator: Laederach, Alain T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.