Improving methods to visualize how tissues function and metabolize substances
Official title: Advancing functional mass spectrometry imaging methodology to monitor dynamic physiological processes
Funded at North Carolina State University Raleigh · NIH-11050361 · Data updated 2026-11-12
This study is exploring a new way to see how tissues in the body use different substances, which could help us understand diseases better, and it's designed for anyone interested in how our bodies work at a deeper level.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | December 13, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $465,028 |
| NIH project number | 1R01CA288969-01A1 |
| Project ID | NIH-11050361 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with metabolic disorders or conditions affecting tissue function.
✕Less likely to help
Patients with stable, non-metabolic related conditions may not receive direct benefits from this research.
What this research studies
This research focuses on developing advanced imaging techniques to monitor how tissues in the body metabolize substances and how this relates to their function. By using a method called functional Mass Spectrometry Imaging (fMSI), researchers aim to capture dynamic changes in tissue perfusion and metabolic activities at a high spatial resolution. The approach involves administering specific isotopically labeled substances to tissues and analyzing their uptake and conversion, which can provide insights into various biological processes. This innovative methodology seeks to bridge the gap between molecular data and tissue functionality, potentially leading to better understanding of diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for various diseases by providing real-time insights into tissue metabolism.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques to study tissue metabolism, indicating that this approach could yield valuable insights.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Gamcsik, Michael — North Carolina State University Raleigh
- Study coordinator: Gamcsik, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.