Improving immune function after traumatic injuries
Official title: Targeting Trained Immunity in Trauma-Induced Immune Dysregulation
Funded at Brigham and Women's Hospital · NIH-11086073 · Data updated 2026-11-12
This study is looking at how serious injuries like burns or major surgeries can weaken the immune system and make it easier for infections to take hold, and it aims to find new treatments that can boost the immune response and help patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 7, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $510,529 |
| NIH project number | 5R01AI177803-03 |
| Project ID | NIH-11086073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced significant traumatic injuries, such as severe burns or major surgical procedures.
✕Less likely to help
Patients with minor injuries or those who do not have significant immune dysregulation may not benefit from this research.
What this research studies
This research investigates how traumatic injuries, such as burns or major surgeries, disrupt the immune system, making patients vulnerable to severe infections. The approach focuses on a concept called 'trained immunity,' which aims to enhance the immune response by modifying innate immune cells. By using specific compounds derived from bacterial DNA, the study seeks to develop new therapies that can help restore immune balance and improve recovery outcomes for patients suffering from trauma-induced complications.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly reduce the risk of infections and improve recovery for trauma patients.
How similar studies have gone: Other research has shown promise in using trained immunity approaches to enhance immune responses, suggesting that this method could be effective in treating trauma-related immune dysfunction.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Lederer, James a. — Brigham and Women's Hospital
- Study coordinator: Lederer, James a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.