Improving how closely patients take their breast cancer medicines with a connected, personalized platform
Official title: Improving medication adherence using a CONnected CUstomized Treatment Platform (CONCURxP)
Funded at University of California-Irvine · NIH-11378178 · Data updated 2026-11-12
A randomized trial will test a text-message–based, personalized support system to help adult women with a certain kind of breast cancer take their prescribed CDK4/6 inhibitor medication more reliably.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 10, 2022 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $440,789 |
| NIH project number | 5R01CA262312-05 |
| Project ID | NIH-11378178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adult women with HR+/HER2- metastatic breast cancer starting a CDK4/6 inhibitor who have a mobile phone with text messaging and speak English or Spanish.
✕Less likely to help
Patients not receiving CDK4/6 inhibitors or those without access to text messaging could see no benefit.
What this research studies
This study targets adult women with HR+/HER2- metastatic breast cancer who are newly prescribed a CDK4/6 inhibitor. Participants will be randomly assigned to receive the CONCURxP support platform in addition to usual care, or enhanced usual care alone, to see if reminders, tailored guidance, and connected tools improve adherence. A smart pillbox will objectively track how well they take their medication, and outcomes will include adherence, symptom burden, quality of life, and survival-related signals. The intervention leverages widespread mobile phone use and telemedicine to adapt to patients’ daily lives. The trial will enroll 390 participants across NCORP practices over several years.
Why it matters
Potential benefit: If successful, patients could experience better treatment adherence, potentially improving survival and quality of life.
How similar studies have gone: Prior studies in cancer care show that digital adherence support can improve medication-taking behavior, though this exact platform is novel.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Sadigh, Gelareh — University of California-Irvine
- Study coordinator: Sadigh, Gelareh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.