Improving heart regeneration using specific proteins
Cardiac regeneration by histone deacetylases
This study is looking at how specific proteins can help the heart heal itself after an injury, with the hope of finding new ways to treat heart disease and heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10864013 on NIH RePORTER |
What this research studies
This research investigates how certain proteins, specifically histone deacetylases, can enhance the heart's ability to regenerate after injury. By studying the differences between developing and adult hearts, the researchers aim to understand how to stimulate heart muscle cells to grow and repair themselves. The approach involves analyzing genetic and molecular changes that occur during heart development and applying this knowledge to adult heart cells. If successful, this could lead to new treatments for heart disease and heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from heart disease or heart failure who may benefit from enhanced cardiac regeneration.
Not a fit: Patients with non-cardiac related health issues or those whose heart conditions are not amenable to regenerative therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapies that significantly improve heart regeneration and recovery for patients with heart disease.
How similar studies have performed: Other research has shown promise in using epigenetic approaches to enhance heart regeneration, indicating that this area of study has potential for success.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Li, Deqiang — Research Inst Nationwide Children's Hosp
- Study coordinator: Li, Deqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.