Improving heart preservation techniques for transplants
Targeting Mineralocorticoid Receptor Condensates to Optimize Donor Heart Preservation
This study is looking at ways to better preserve donor hearts for heart transplant patients by exploring how certain receptors in the heart can help reduce problems after surgery, with the hope of making transplants more successful and improving patient outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11010868 on NIH RePORTER |
What this research studies
This research focuses on enhancing the preservation of donor hearts to improve outcomes for heart transplant patients. It investigates the role of mineralocorticoid receptors in heart function and how their antagonism can reduce primary graft dysfunction, a significant complication in heart transplants. By using animal models and human heart samples, the study aims to understand the molecular mechanisms involved in heart preservation and improve the viability of donor hearts during transplantation. The ultimate goal is to optimize donor heart function and increase the success rates of heart transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with end-stage heart failure who are awaiting heart transplantation.
Not a fit: Patients who are not candidates for heart transplantation or those with non-cardiac related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart transplant outcomes and increased availability of viable donor hearts.
How similar studies have performed: Previous research has shown promising results in improving heart preservation techniques, indicating that this approach has potential for success.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Tang, Paul — Mayo Clinic Rochester
- Study coordinator: Tang, Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.