Improving bone healing in older adults
A novel target in aged fracture healing
This study is looking at how a protein called ApoE affects how well older adults heal from bone fractures, and it aims to find a way to lower ApoE levels to help improve recovery for those with broken bones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11080964 on NIH RePORTER |
What this research studies
This research investigates how a protein called Apolipoprotein E (ApoE) affects the healing of bone fractures in older adults. The study aims to reduce the negative impact of aging on bone repair by using a targeted approach to lower ApoE levels in the body. By delivering a specific treatment to inhibit ApoE, researchers hope to enhance the body's natural ability to heal fractures. The ultimate goal is to develop new therapies that can be used in clinical settings to improve recovery outcomes for elderly patients with fractures.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced bone fractures and may have impaired healing due to age-related factors.
Not a fit: Patients who are younger or do not have issues with bone healing related to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve bone healing in older adults, reducing complications and the need for additional surgeries.
How similar studies have performed: Previous research has shown promising results in targeting ApoE to improve bone healing, indicating that this approach may be effective.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Baht, Gurpreet — Duke University
- Study coordinator: Baht, Gurpreet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.