IMPILO: New 6-month RR-TB regimen in pregnant and breastfeeding women
Official title: IMPILO: Investigating novel 6-Month regimens for RR-TB in Pregnancy and Lactation
Funded at Medical Research Council of South Africa · NIH-11421467 · Data updated 2026-11-12
A study in pregnant and postpartum women with rifampicin-resistant TB will track how well a new all-oral 6-month treatment works and how well people stick to it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical Research Council of South Africa NIH-funded |
| Lab location | 1 site (Cape Town, South Africa) |
| Project start | May 10, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $120,689 |
| NIH project number | 5R01AI183355-03 |
| Project ID | NIH-11421467 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant or postpartum women with rifampicin-resistant TB, and women of childbearing potential with RR-TB.
✕Less likely to help
Women without RR-TB or those not planning pregnancy may not benefit from this specific regimen.
What this research studies
This project will enroll pregnant and postpartum women with RR-TB and follow them to see how reliably they take the new all-oral 6-month regimen. Researchers will use electronic devices to monitor adherence and screen for depression, since mood changes can affect how well medicines are taken. The study will compare adherence between pregnant and non-pregnant participants and between pregnancy and the postpartum period, providing real-world data from South Africa. The goal is to identify factors that influence adherence so interventions can be developed to support patients through pregnancy and after birth.
Why it matters
Potential benefit: If successful, the regimen could lead to better treatment completion and healthier outcomes for mothers and their babies.
How similar studies have gone: There is limited data on RR-TB regimens during pregnancy, so findings will inform future care.
Where this research is happening
-
Medical Research Council of South Africa
Cape Town, South Africa Active
Researchers
- Principal investigator: Loveday, Marian — Medical Research Council of South Africa
- Study coordinator: Loveday, Marian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.