Identifying genes that affect kidney disease using zebrafish
Discovering ADPKD Modifier Genes and Therapies via Zebrafish Genetics
This study is looking at how certain genes might affect the severity of Autosomal Dominant Polycystic Kidney Disease (ADPKD) using zebrafish to help find new ways to treat the condition, which could ultimately benefit patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10915786 on NIH RePORTER |
What this research studies
This research aims to discover genetic factors that influence the severity of Autosomal Dominant Polycystic Kidney Disease (ADPKD) by using adult zebrafish as a model organism. The researchers will develop zebrafish mutants that mimic human kidney disease and utilize innovative genetic screening methods to identify protective genes. By validating these findings, the study seeks to enhance our understanding of ADPKD and potentially lead to new therapeutic strategies. Patients may benefit from insights gained into their condition and the development of targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease.
Not a fit: Patients without a diagnosis of ADPKD or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with ADPKD.
How similar studies have performed: Previous research has successfully utilized zebrafish models to study genetic diseases, indicating a promising approach for this investigation.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Xu, Xiaolei — Mayo Clinic Rochester
- Study coordinator: Xu, Xiaolei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.