Identifying genes that affect kidney disease using zebrafish
Official title: Discovering ADPKD Modifier Genes and Therapies via Zebrafish Genetics
Funded at Mayo Clinic Rochester · NIH-10915786 · Data updated 2026-11-12
This study is looking at how certain genes might affect the severity of Autosomal Dominant Polycystic Kidney Disease (ADPKD) using zebrafish to help find new ways to treat the condition, which could ultimately benefit patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 20, 2023 |
| Project end | September 19, 2025 |
| Funding year | 2023 |
| Award (this year) | $100,000 |
| NIH project number | 1R56DK137778-01 |
| Project ID | NIH-10915786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease.
✕Less likely to help
Patients without a diagnosis of ADPKD or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research aims to discover genetic factors that influence the severity of Autosomal Dominant Polycystic Kidney Disease (ADPKD) by using adult zebrafish as a model organism. The researchers will develop zebrafish mutants that mimic human kidney disease and utilize innovative genetic screening methods to identify protective genes. By validating these findings, the study seeks to enhance our understanding of ADPKD and potentially lead to new therapeutic strategies. Patients may benefit from insights gained into their condition and the development of targeted treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with ADPKD.
How similar studies have gone: Previous research has successfully utilized zebrafish models to study genetic diseases, indicating a promising approach for this investigation.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Xu, Xiaolei — Mayo Clinic Rochester
- Study coordinator: Xu, Xiaolei
Related research
Other NIH-funded projects on the same topics.
-
All of Us Biobank expansion and biospecimen program
A large Mayo Clinic–led project to collect and store biological samples from a diverse group of adults in the U.S. to advance precision medicine.
-
How baclofen and spinal cord stimulation interact in people with spinal cord injury
This study looks at how a common antispasmodic medicine (baclofen) works together with spinal cord stimulation in people who have spinal cord injuries and live with spasticity.
-
Pragmatic midodrine trial to reduce ICU vasopressor use in septic shock
A practical, patient-focused trial tests whether taking oral midodrine can lessen the need for IV vasopressors and shorten ICU stays for people with sepsis-related low blood pressure.
-
Estrogen’s role in eye pressure and glaucoma risk
A Mayo Clinic team is studying how estrogen and its receptors might control eye pressure in people with a common form of glaucoma.
-
Gut-brain connections in Parkinson’s disease: how the gut and environment shape symptoms
A Mayo Clinic team is studying how gut problems, environmental factors, and genetics together influence Parkinson’s disease and its GI symptoms to find biomarkers and better understanding of the disease.
-
ARTFL LEFFTDS Frontotemporal Dementia study cycle 2
This NIH grant supports a longitudinal study to understand and track frontotemporal lobar degeneration (FTLD) and related disorders in people, aiming to uncover biomarkers and disease progression information that could help patients and families.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.