Identifying genes linked to orofacial clefts using genetic data
Official title: Rare variant analysis integrating large public DNA sequencing controls and gene expression data for discovering novel predisposition genes of orofacial clefts
Funded at Mayo Clinic Rochester · NIH-11125052 · Data updated 2026-11-12
This study is looking at the genes that might cause orofacial clefts, like cleft lip and palate, to help us understand these conditions better and find ways to diagnose and treat them earlier for those who are affected.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | June 10, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $320,800 |
| NIH project number | 1R03OD039975-01 |
| Project ID | NIH-11125052 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children under the age of 11 who have been diagnosed with orofacial clefts.
✕Less likely to help
Patients with orofacial clefts who are over the age of 11 or do not have a genetic predisposition may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to orofacial clefts, such as cleft lip and palate, by analyzing large datasets of DNA sequences and gene expression. The study aims to identify rare genetic variants that may predispose individuals to these conditions, utilizing a combination of genetic burden analyses and transcriptomics data from various sources. By integrating information from thousands of samples, the research seeks to enhance our understanding of the genetic basis of orofacial clefts, which could lead to earlier diagnosis and targeted therapies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for children with orofacial clefts.
How similar studies have gone: Previous research has shown promise in identifying genetic factors associated with other congenital conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Chen, Wenan — Mayo Clinic Rochester
- Study coordinator: Chen, Wenan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.