Identifying brain-based markers for predicting psychosis risk
Official title: Identification of Distinct Biotypes in Clinical High Risk for Psychosis State Using Objective Brain-Based Biomarkers
Funded at Beth Israel Deaconess Medical Center · NIH-10772165 · Data updated 2026-11-12
This study is looking at how certain brain signals can help spot people who are at a higher risk of developing psychosis, so we can better understand their needs and provide the right support.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $155,207 |
| NIH project number | 5R21MH133001-02 |
| Project ID | NIH-10772165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals identified as being at clinical high risk for psychosis, which may include those with early symptoms or family histories of psychotic disorders.
✕Less likely to help
Patients who are not at clinical high risk for psychosis or those with established psychotic disorders may not benefit from this research.
What this research studies
This research investigates how distinct brain-based biomarkers can help identify individuals at clinical high risk for developing psychosis. By analyzing a variety of cognitive and electrophysiological data, the study aims to classify patients into specific biotypes that reflect their unique clinical trajectories. This approach seeks to improve predictions about who may develop psychosis and tailor interventions accordingly. Patients participating in this research may undergo assessments that include brain imaging and cognitive tests to gather comprehensive data.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions and personalized treatment strategies for individuals at risk of psychosis.
How similar studies have gone: Previous research has shown promise in using neurobiological markers to predict psychosis risk, but this approach aims to refine and validate these methods further.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Yassine, Walid — Beth Israel Deaconess Medical Center
- Study coordinator: Yassine, Walid
Related research
Other NIH-funded projects on the same topics.
-
Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
-
Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
-
A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
-
Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
-
Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
-
Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.