Identifying a new biomarker for ALS using brain stimulation techniques
Official title: Failure of Facilitation as a Biomarker in ALS
Funded at Northeastern University · NIH-10885189 · Data updated 2026-11-12
This study is looking at a new way to use a technique called transcranial magnetic stimulation (TMS) to help doctors spot amyotrophic lateral sclerosis (ALS) earlier and better understand how it progresses, which could lead to improved care and treatment for people living with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 11, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $206,001 |
| NIH project number | 5R21NS130936-02 |
| Project ID | NIH-10885189 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis (ALS) or those exhibiting early symptoms of the disease.
✕Less likely to help
Patients with other neurological disorders or those who do not have ALS will likely not benefit from this research.
What this research studies
This research investigates the use of transcranial magnetic stimulation (TMS) to measure a specific response called 'Failure of Facilitation' in patients with amyotrophic lateral sclerosis (ALS). By assessing the functional integrity of motor neurons, the study aims to establish this response as a reliable biomarker for diagnosing ALS earlier and tracking its progression. The goal is to improve diagnostic accuracy and patient management, ultimately enhancing treatment options for individuals affected by this rapidly progressing disease.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of ALS, improving the quality of life for patients.
How similar studies have gone: Previous research has shown promise in using biomarkers for neurological diseases, suggesting that this approach may yield valuable insights for ALS as well.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Tunik, Eugene — Northeastern University
- Study coordinator: Tunik, Eugene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.