Administrative supplement to extend IGVF work on variant interpretation
Official title: Administrative Supplement for IGVF Cost Extension
Funded at Northeastern University · NIH-11523090 · Data updated 2026-11-12
A one-year extension to finish and expand resources that help scientists interpret genetic variants and predict their effects on health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2021 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $564,812 |
| NIH project number | 3U01HG012022-05S1 |
| Project ID | NIH-11523090 on NIH RePORTER |
Who could benefit from this research
✓Could help
This grant is aimed at researchers and clinicians interpreting genetic variants in human diseases, not a specific patient population.
✕Less likely to help
Direct patient participation is not part of this grant; it focuses on methodological development and resources.
What this research studies
This grant extends ongoing work that has created calibration frameworks and new methods to interpret genetic variants. It includes expanding ExCALIBR to handle multiple data types, improving automated flagging of benign variants, and integrating diverse evidence to guide experiments. The goal is to finish key activities that support better understanding of how variants impact health and to share resources with the genomics community. The work is led by Northeastern University researchers and collaborators within the IGVF consortium.
Why it matters
Potential benefit: If successful, patients could benefit from faster, more accurate interpretation of genetic variants that influence disease risk and treatment decisions.
How similar studies have gone: Previous efforts have produced widely used calibration frameworks and prediction tools, with substantial adoption in the field.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Radivojac, Predrag — Northeastern University
- Study coordinator: Radivojac, Predrag
Related research
Other NIH-funded projects on the same topics.
-
Mediators and Modulators of Executive Function Training in Older Adults
A large study to understand what parts of brain-training programs for older adults help or hinder engagement and improvements in thinking skills.
-
Ultra-low-power ML brain implants to help manage Alzheimer’s and related disorders
A project to create a tiny, energy-saving brain-monitoring device with smart software that can help detect and manage Alzheimer’s-related conditions in real time.
-
AI-powered video guidance to help blind and low-vision people do daily tasks
A hospital-style grant is funding a wearable glasses system that gives BLV individuals real-time, step-by-step video instructions to do everyday tasks.
-
Precision laser-assisted brain tumor surgery using gigahertz pulse bursts
A new brain tumor surgery method uses real-time imaging and ultra-precise laser bursts to remove cancer cells while sparing healthy brain tissue.
-
Combined peer support and online program to help HIV prevention for youths
A youth-focused program combines a web-based alcohol/sexual risk intervention with peer counseling and navigation to reduce HIV risk and alcohol use.
-
Finding medicines for understudied human proteins using AI
Researchers are using AI plus large-scale chemical proteomics to find which small molecules bind and change the activity of understudied human proteins that may be linked to disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.