How the nervous system affects heart function and arrhythmias
Official title: Neural Control of Myocardial Excitability at the Nerve Myocyte Interface
Funded at University of California Los Angeles · NIH-10904660 · Data updated 2026-11-12
This study is looking at how nerve signals in the heart change when someone has heart problems like arrhythmias or heart failure, especially in areas with damage, to help find better ways to treat these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $483,019 |
| NIH project number | 5P01HL164311-02 |
| Project ID | NIH-10904660 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with heart disease, particularly those experiencing arrhythmias or heart failure.
✕Less likely to help
Patients without heart disease or those who do not experience arrhythmias may not benefit from this research.
What this research studies
This research investigates the role of the autonomic nervous system in heart conditions like arrhythmias and heart failure. It focuses on how nerve signals and neurotransmitter release in the heart can change due to heart disease, particularly in areas with myocardial scars. By examining the structural and functional changes in the heart, the research aims to understand how these alterations contribute to dangerous heart rhythms. The findings could lead to new therapeutic approaches for managing heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients at risk of sudden cardiac death due to arrhythmias.
How similar studies have gone: Previous research has shown that understanding the nervous system's role in heart function can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Shivkumar, Kalyanam — University of California Los Angeles
- Study coordinator: Shivkumar, Kalyanam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.