How the nervous system affects heart function and arrhythmias
Neural Control of Myocardial Excitability at the Nerve Myocyte Interface
This study is looking at how nerve signals in the heart change when someone has heart problems like arrhythmias or heart failure, especially in areas with damage, to help find better ways to treat these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10904660 on NIH RePORTER |
What this research studies
This research investigates the role of the autonomic nervous system in heart conditions like arrhythmias and heart failure. It focuses on how nerve signals and neurotransmitter release in the heart can change due to heart disease, particularly in areas with myocardial scars. By examining the structural and functional changes in the heart, the research aims to understand how these alterations contribute to dangerous heart rhythms. The findings could lead to new therapeutic approaches for managing heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with heart disease, particularly those experiencing arrhythmias or heart failure.
Not a fit: Patients without heart disease or those who do not experience arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients at risk of sudden cardiac death due to arrhythmias.
How similar studies have performed: Previous research has shown that understanding the nervous system's role in heart function can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Shivkumar, Kalyanam — University of California Los Angeles
- Study coordinator: Shivkumar, Kalyanam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.