Impact of PrEP drugs on HIV prevention and women's reproductive health
Effects of PrEP Drugs on Female Genital HIV Infection and Women's Reproductive Health
This study is looking at how PrEP medications can help prevent HIV in young women and whether they affect women's reproductive health, including fertility and pregnancy, by examining how different factors in the body might change how well these medications work.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10703238 on NIH RePORTER |
What this research studies
This research investigates how pre-exposure prophylactic (PrEP) drugs affect HIV transmission and women's reproductive health, particularly focusing on young women at risk of HIV. It aims to understand the biological and anatomical differences in the female reproductive tract that may influence PrEP efficacy. The study will explore how factors like inflammation and the presence of semen can impact both HIV infection rates and the effectiveness of PrEP. Additionally, it will assess whether PrEP drugs have any adverse effects on fertility and pregnancy processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are young women of reproductive age who are at risk of HIV infection.
Not a fit: Patients who are not at risk of HIV or those who are not of reproductive age may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved PrEP strategies that enhance HIV prevention and support women's reproductive health.
How similar studies have performed: While PrEP has been effective in preventing HIV in men, this research addresses a less explored area regarding its impact on women, making it a novel investigation.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: George, Ashley F — J. David Gladstone Institutes
- Study coordinator: George, Ashley F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.