How platelets affect complications after ischemic stroke
Official title: Platelets as regulator of non-neurological complications of ischemic stroke
Funded at Thomas Jefferson University · NIH-11049488 · Data updated 2026-11-12
This study is looking at how platelets, which are tiny cells in your blood, can cause problems in other parts of your body after you've had an ischemic stroke, and it's hoping to find new ways to help stroke patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 15, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $779,952 |
| NIH project number | 1R01HL173436-01A1 |
| Project ID | NIH-11049488 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an ischemic stroke and are at risk for complications during recovery.
✕Less likely to help
Patients who have not had a stroke or those with non-ischemic stroke types may not benefit from this research.
What this research studies
This research investigates the role of platelets in causing complications following ischemic stroke, which occurs when blood clots block blood flow to the brain. The study aims to understand how activated platelets can lead to damage in other organs, such as the lungs and intestines, after a stroke. By exploring the mechanisms of platelet activity, the research seeks to develop new therapies that could mitigate these complications and improve recovery outcomes for stroke patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce complications and improve recovery for stroke patients.
How similar studies have gone: While the role of platelets in stroke recovery is being explored, this specific approach to targeting platelet activity for reducing complications is relatively novel.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Naik, Ulhas P — Thomas Jefferson University
- Study coordinator: Naik, Ulhas P
Related research
Other NIH-funded projects on the same topics.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
EP2 blockers to protect the brain after a stroke
Aims to test brain-permeable EP2 antagonists to reduce damage after ischemic stroke and improve recovery.
-
Genetic testing to find causes of early-onset ischemic stroke
This project uses whole-exome sequencing to look for gene changes that may cause ischemic stroke in adults who had a stroke at a young age.
-
Targeted nanomedicine to protect the brain after stroke
A targeted drug-delivery approach aims to boost blood-brain barrier repair and reduce brain damage after an acute ischemic stroke in patients at risk.
-
How biological aging and blood proteins relate to thinking after a stroke
This project looks at whether measures of biological aging and patterns of blood proteins help explain which stroke survivors keep their thinking sharp and which go on to develop vascular dementia.
-
Repurposing NEXLETOL to treat ischemic stroke
Aims to see if the cholesterol drug NEXLETOL can help people after an ischemic stroke by supporting brain energy use and reducing injury.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.