How parasitic worms alter immunity and inflammation signals
Molecular mayhem: Immune modulation and eicosanoid signaling during infection
This research explores molecules made by parasitic worms that change immune responses and inflammation and could point to new treatments for autoimmune gut conditions like Crohn's disease and celiac disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11261002 on NIH RePORTER |
What this research studies
The team will identify proteins and small molecules that parasitic nematodes release during infection and will begin detailed work on a group called FAR proteins. They will analyze parasite secretions in the lab and map how these molecules interact with host immune and eicosanoid signaling pathways. Experiments will include biochemical characterization and tests of effects on immune cells and tissues using cell models and likely animal models to reveal mechanisms. The project aims to learn how parasites suppress or redirect immunity to inspire new ways to dampen harmful inflammation.
Who could benefit from this research
Good fit: People with autoimmune digestive conditions such as Crohn's disease or celiac disease who are willing to donate samples or consider future trials of therapies based on parasite molecules would be most relevant.
Not a fit: Patients seeking immediate treatment or symptom relief should not expect direct or immediate benefit from this laboratory-focused research.
Why it matters
Potential benefit: If successful, this work could reveal parasite-derived molecules that lead to new treatments to reduce harmful inflammation in autoimmune gut diseases.
How similar studies have performed: Related lab and animal studies have shown parasite-derived molecules can change immune responses, but therapies for people based on these molecules remain largely unproven.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Dillman, Adler Ray — University of California Riverside
- Study coordinator: Dillman, Adler Ray
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.