How parasites change the immune response in humans
Molecular mayhem: Immune modulation and eicosanoid signaling during infection
This study looks at how tiny worms called parasitic nematodes can change how our immune system works when they infect us, with the goal of finding new ways to help our bodies fight off infections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10874691 on NIH RePORTER |
What this research studies
This research investigates how parasitic nematodes can alter the immune response of their human hosts. By studying the proteins and small molecules released by these parasites during infection, the research aims to uncover how they evade or suppress the immune system. The approach includes identifying key genetic pathways involved in lipid-mediated immune signaling and characterizing the interactions between parasite-derived molecules and host cells. This could lead to new insights into immune modulation and potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from autoimmune diseases or conditions related to immune dysregulation.
Not a fit: Patients with non-autoimmune conditions or those not affected by immune system issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases by harnessing the mechanisms used by parasites to manipulate the immune system.
How similar studies have performed: Previous research has shown promise in understanding host-parasite interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Dillman, Adler Ray — University of California Riverside
- Study coordinator: Dillman, Adler Ray
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.