How mycobacteria regulate energy production
Official title: Ion channel regulation of ATP homeostasis in mycobacteria
Funded at Temple Univ of the Commonwealth · NIH-10826312 · Data updated 2026-11-12
This study is looking at how certain channels in tuberculosis bacteria help them produce energy, which could explain why some strains are hard to treat, and the findings might lead to better treatments for people with tuberculosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 10, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $332,850 |
| NIH project number | 1R01GM150218-01A1 |
| Project ID | NIH-10826312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals diagnosed with tuberculosis, especially those with multi-drug resistant strains.
✕Less likely to help
Patients with non-infectious diseases or those not affected by tuberculosis will not receive any benefit from this research.
What this research studies
This research investigates the role of ion channels in the regulation of ATP production in Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By focusing on a specific gene that may influence ATP synthesis, the study aims to understand how these bacteria survive and resist treatment, particularly in cases of multi-drug resistance. The researchers will use genetic techniques and model organisms to explore how manipulating these channels can affect energy levels in the bacteria, potentially leading to new treatment strategies. Patients with tuberculosis may benefit from insights gained through this research, which could lead to more effective therapies.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for tuberculosis, particularly for drug-resistant strains.
How similar studies have gone: Previous research has shown promise in targeting ATP synthesis pathways in bacteria, indicating that this approach could be effective in developing new treatments.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Rothberg, Brad S. — Temple Univ of the Commonwealth
- Study coordinator: Rothberg, Brad S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.