How kidney issues affect hand function in dialysis patients
Impaired Mitochondrial Energetics is a Driver of Hemodialysis Access Related Hand Dysfunction
This study is looking at how kidney problems might cause hand issues in people on dialysis, and it hopes to find ways to prevent or improve these hand problems by understanding the changes happening in the body during treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10694865 on NIH RePORTER |
What this research studies
This research investigates the connection between kidney dysfunction and hand problems in patients undergoing hemodialysis. It focuses on how changes in mitochondrial function and increased oxidative stress may lead to muscle and nerve issues after surgery for creating access points for dialysis. By understanding these mechanisms, the research aims to identify ways to prevent or reverse hand dysfunction in these patients, potentially through early intervention or treatment modifications. The study will involve analyzing patient data and physiological responses to better understand the underlying causes of these complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing hemodialysis who experience or are at risk for hand dysfunction following arteriovenous fistula surgery.
Not a fit: Patients who are not undergoing hemodialysis or do not have hand dysfunction related to their treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing hand dysfunction in hemodialysis patients, enhancing their quality of life.
How similar studies have performed: Previous research has indicated that addressing mitochondrial dysfunction and oxidative stress can lead to improvements in muscle function, suggesting potential success for this approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Scali, Salvatore T. — University of Florida
- Study coordinator: Scali, Salvatore T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.