How kidney issues affect hand function in dialysis patients
Official title: Impaired Mitochondrial Energetics is a Driver of Hemodialysis Access Related Hand Dysfunction
Funded at University of Florida · NIH-10694865 · Data updated 2026-11-12
This study is looking at how kidney problems might cause hand issues in people on dialysis, and it hopes to find ways to prevent or improve these hand problems by understanding the changes happening in the body during treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 5, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $515,943 |
| NIH project number | 5R01HL148597-05 |
| Project ID | NIH-10694865 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing hemodialysis who experience or are at risk for hand dysfunction following arteriovenous fistula surgery.
✕Less likely to help
Patients who are not undergoing hemodialysis or do not have hand dysfunction related to their treatment may not benefit from this research.
What this research studies
This research investigates the connection between kidney dysfunction and hand problems in patients undergoing hemodialysis. It focuses on how changes in mitochondrial function and increased oxidative stress may lead to muscle and nerve issues after surgery for creating access points for dialysis. By understanding these mechanisms, the research aims to identify ways to prevent or reverse hand dysfunction in these patients, potentially through early intervention or treatment modifications. The study will involve analyzing patient data and physiological responses to better understand the underlying causes of these complications.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing hand dysfunction in hemodialysis patients, enhancing their quality of life.
How similar studies have gone: Previous research has indicated that addressing mitochondrial dysfunction and oxidative stress can lead to improvements in muscle function, suggesting potential success for this approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Scali, Salvatore T. — University of Florida
- Study coordinator: Scali, Salvatore T.
Related research
Other NIH-funded projects on the same topics.
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Optimizing a prehabilitation program for kidney transplant candidates on dialysis
A program to improve physical function and readiness for kidney transplant in people on dialysis is being developed and tested to help candidates stay healthier while they wait.
-
Simulator-based training to improve dialysis needle skills for patients with kidney failure
A new simulator-based curriculum will train dialysis care providers to position and insert needles more safely and consistently for people with end-stage kidney disease.
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Implanted dialysis device for safe, easy at-home hemodialysis
A new implanted dialysis cartridge and at-home system aim to let people with kidney failure dialyze themselves more safely and conveniently at home.
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Improving how patients choose their hemodialysis access
A patient-friendly project to help people with kidney failure better understand and decide between AV fistula, graft, or catheter for hemodialysis.
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IVUS in AV access dysfunction for hemodialysis patients
A new approach tests whether using intravascular ultrasound (IVUS) in people with failing AV fistulas or grafts improves diagnosis and guides treatment to prevent more blockages.
-
StepNet-Adapt: a personalized mobile program to boost activity for people on dialysis
A personalized mobile health program uses wearables, texts, and coaching to help people on hemodialysis become more physically active.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.